A novel polymorphism in a FOXA1 binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α, 17β- diol glucuronide
نویسندگان
چکیده
Department of Clinical Pharmacology, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia (DGH, DGS, PIM), Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia (GS, GGG, DRE), Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, University of Melbourne, Melbourne, Australia (GS, GGG, DRE, JLH), Centre for Cancer Biology, SA Pathology, Adelaide, SA 5000, Australia and Discipline of Medicine, The University of Adelaide, Adelaide, SA, Australia 5005 (PAG), Dame Roma Mitchell Cancer Research Laboratories, Discipline of Medicine, University of Adelaide, Hanson Institute, Adelaide, SA 5005, Australia (JT, WDT). Molecular Pharmacology Fast Forward. Published on July 13, 2010 as doi:10.1124/mol.110.065953
منابع مشابه
A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide.
UDP glucuronosyltransferase 2B17 is present in the prostate, where it catalyzes the addition of glucuronic acid to testosterone and dihydrotestosterone and their metabolites androsterone and androstane-3α,17β-diol. Hence, changes in UGT2B17 gene expression may affect the capacity of the prostate to inactivate and eliminate male sex hormones. In this work, we identify a prevalent polymorphism, -...
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